Why the study?
Does chronic hypertension impair endothelium-dependent cerebral vasodilatation in response to bradykinin and calcium ionophore in rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive WKY rats (9-12 months old)
Comparison
Superfusion of bradykinin (3 x 10 M) and calcium… vs Normotensive WKY rats
Design
Preclinical
Authors
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Hypothesis-generating for endothelial dysfunction in hypertensive cerebral vessels; human translation requires prospective study.
Does chronic hypertension impair endothelium-dependent cerebral vasodilatation in response to bradykinin and calcium ionophore in rats?
Chronic hypertension in stroke-prone rats impairs endothelium-dependent cerebral vasodilatation in response to bradykinin and calcium ionophore, suggesting altered postreceptor mechanisms.
Yang et al. (1991) studied this question.
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