Why the study?
Does selective activation of endothelin-B receptors alter basilar artery responses in stroke-prone spontaneously hypertensive rats compared to normotensive rats?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY)
Comparison
Topical application of IRL 1620 (10 mol/L), a… vs Normotensive Wistar-Kyoto rats (WKY)
Design
Preclinical
Authors
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Enhanced basilar dilation to endothelin-B activation in hypertensive rats is hypothesis-generating; leaves open translation to human cerebrovascular disease.
Does selective activation of endothelin-B receptors alter basilar artery responses in stroke-prone spontaneously hypertensive rats compared to normotensive rats?
Dilator responses of the basilar artery to selective activation of endothelin-B receptors are paradoxically enhanced in stroke-prone spontaneously hypertensive rats and do not depend on nitric oxide or prostanoids.
Kitazono et al. (1995) studied this question.
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