What question did this study set out to answer?

The study aims to evaluate whether endothelium-dependent responses are compromised in the cerebral arterioles of stroke-prone spontaneously hypertensive rats.

December 1, 1987AJP Heart and Circulatory Physiology

Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension

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Why the study?

Does chronic hypertension impair endothelium-dependent responses of cerebral arterioles in stroke-prone spontaneously hypertensive rats?

Key Points

The study aims to evaluate whether endothelium-dependent responses are compromised in the cerebral arterioles of stroke-prone spontaneously hypertensive rats.
Measured diameters of cerebral arterioles using intravital microscopy in normotensive (WKY) and hypertensive rats (SHRSP).
Administered endothelium-dependent agonists (acetylcholine and serotonin) and assessed the vascular responses.
Compared vasodilatory responses between WKY and SHRSP.
Cerebral vasodilator response to acetylcholine was 23% in WKY but -2% in SHRSP (P<0.05).
Serotonin increased diameter by 23% in WKY but reduced diameter by 11% in SHRSP (P<0.05).
Nitroglycerin produced similar vasodilation in both WKY and SHRSP, indicating cGMP activity is not impaired.

Structured PICO

Does chronic hypertension impair endothelium-dependent responses of cerebral arterioles in stroke-prone spontaneously hypertensive rats?

Population

Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive rats (WKY), 6-8 months old

Intervention

Superfusion with endothelium-dependent agonists (acetylcholine, serotonin) and endothelium-independent agonists (adenosine, nitroglycerin)

Comparator

Normotensive rats (WKY)

Outcome

Changes in diameters of cerebral arterioles measured using intravital microscopysurrogate

Chronic hypertension profoundly impairs endothelium-dependent cerebral vasodilator responses in stroke-prone spontaneously hypertensive rats, which may predispose them to cerebral ischemia.

Discussion

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Implication

Impaired cerebral arteriolar responses in hypertensive rats may heighten ischemia vulnerability; leaves open translation to human stroke risk.

Cite This Study

Mayhan et al. (1987) studied this question.

synapsesocial.com/papers/6a72343cb27f15817827f86f https://doi.org/10.1152/ajpheart.1987.253.6.h1435

Topics

Hypertension management

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Implication

Impaired cerebral arteriolar responses in hypertensive rats may heighten ischemia vulnerability; leaves open translation to human stroke risk.

Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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