Population
Segments of distal mesenteric arteries from spontaneously hypertensive rats at 5 and 20 weeks of age
Comparison
In vitro isolation and pressurization of… vs Vessels from age-matched Wistar-Kyoto control…
Design
Preclinical
Authors
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Does not support sustained myogenic tone changes in established hypertension; hypothesis-generating for developmental vascular mechanisms in SHR models.
Myogenic tone in mesenteric arteries is enhanced during the early developmental phase of hypertension but normalizes in the established phase, except at very high pressures.
Izzard et al. (1996) studied this question.
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