What is the clinical evidence from this study?

Population: Hypertension. Intervention: Spontaneous hypertension (SHR strain) vs. Wistar-Kyoto rats (WKY). Primary outcome: Myogenic tone (pressure-diameter relationships).

What question did this study set out to answer?

The research aims to study myogenic tone in coronary arteries from spontaneously hypertensive and control rats under different pressure conditions.

September 24, 2008Journal of Vascular Research

Myogenic Tone in Coronary Arteries from Spontaneously Hypertensive Rats

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Key result

Spontaneously hypertensive rat coronary arteries generated more myogenic tone than controls only at pressures >140 mm Hg, and demonstrated greater endothelium-mediated antagonism of tone.

Population

Cannulated coronary arteries from spontaneously hypertensive rats and Wistar-Kyoto rats at 5 and 20 weeks of…

Comparison

Pressure-diameter relationship assessment under… vs Wistar-Kyoto rats (WKY) as normotensive controls

Design

Preclinical

Authors

SGSusana R. GarciaManchester Royal Infirmary AIAshley S. IzzardUniversity of Manchester AHAnthony M. HeagertyPreventive Cardiology

Discussion

Member takes

Implication

Rat coronary myogenic differences by strain and age warrant clinical caution; leaves open human hypertensive translation.

Key Points

The research aims to study myogenic tone in coronary arteries from spontaneously hypertensive and control rats under different pressure conditions.
Cannulated coronary arteries from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were studied at 5 and 20 weeks of age.
Pressure-diameter relationships were examined under calcium presence and absence at pressures between 20 to 200 mm Hg.
Comparative analysis of active and passive myogenic tone was conducted at specified ages and pressures.
Active diameter-pressure responses differed significantly between SHR and WKY rats at higher pressures, particularly in the SHR.
Endothelium denudation led to increased myogenic tone in SHR compared to WKY rats at both 5 and 20 weeks.
Maximum myogenic tone was comparable across strains despite differences in wall thickness in SHR.

Structured PICO

Population

Coronary arteries from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) at 5 and 20 weeks of age.

Exposure

Pressure-diameter relationship assessment (20-200 mm Hg) under pressurised no-flow conditions, with and without endothelium denudation

Comparator

Wistar-Kyoto rats (WKY) as normotensive controls

Outcome

Myogenic tone (calculated from active and passive pressure-diameter relationships)surrogate

Spontaneously hypertensive rats exhibit greater endothelium-mediated antagonism of myogenic tone in coronary arteries compared to normotensive controls.

Cite This Study

Garcia et al. (2008) studied Hypertension. Spontaneous hypertension (SHR strain) vs. Wistar-Kyoto rats (WKY) was evaluated on Myogenic tone (pressure-diameter relationships). Spontaneously hypertensive rat coronary arteries generated more myogenic tone than controls only at pressures >140 mm Hg, and demonstrated greater endothelium-mediated antagonism of tone.

synapsesocial.com/papers/6a62def07adcec45b06a6e2e https://doi.org/10.1159/000159208

Topics

Hypertension management

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Myogenic Tone in Coronary Arteries from Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Myogenic Tone in Coronary Arteries from Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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