Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) controls at 5 and 20 weeks of age
Comparison
Assessment of morphological and contractile… vs Wistar-Kyoto (WKY) control rats
Design
Preclinical
Authors
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Structural remodeling in SHR arteries does not alter lumen or contractility; leaves open its role in hypertension pathogenesis.
In spontaneously hypertensive rats, the increased wall-lumen ratio of distal mesenteric arteries does not lead to increased contractility under physiological isobaric conditions.
Izzard et al. (1996) studied this question.
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