Population
Spontaneously hypertensive rats and Wistar-Kyoto rat normotensive controls
Comparison
Vasoconstrictor agonists noradrenaline and… vs WKY normotensive control arteries
Design
Preclinical
Authors
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Remodeling does not enhance femoral contractility in SHR; leaves open differential mesenteric responses and translation to human hypertension.
Increased media thickness to lumen diameter ratio in SHR femoral resistance arteries does not impart an exaggerated contractile function in vitro, though mesenteric arteries show some increased contractile responses.
Stuart J. Bund (2000) studied this question.
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