Population
Spontaneously hypertensive rats and Wistar-Kyoto normotensive control rats
Comparison
In vitro pressurization vs Wistar-Kyoto (WKY) normotensive control rats
Design
Preclinical
Authors
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Vascular remodeling normalizes wall stress in SHR without altering myogenic responses; hypothesis-generating for human hypertension mechanisms, requiring clinical validation.
Increased media thickness/lumen diameter ratios in resistance arteries from spontaneously hypertensive rats act to normalize wall stress without increasing maximum pressure-dependent contractile responses or vessel wall stiffness.
Stuart J. Bund (2001) studied this question.
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