May 1, 1986AJP Heart and Circulatory Physiology

Enhanced response of arterioles to oxygen during development of hypertension in SHR

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Why the study?

Does elevated oxygen exposure increase arteriole constriction in spontaneously hypertensive rats compared to normotensive controls?

Population

Spontaneously hypertensive rats in the early and rapidly developing stages of hypertension, and age-matched…

Comparison

Elevation of superfusion solution PO2 after… vs Age-matched normotensive Wistar-Kyoto controls…

Design

Preclinical

Authors

JLJulian H. LombardMedical College of Wisconsin MHM. E. Hess WSWilliam J. StekielMedical College of Wisconsin

Discussion

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Implication

May implicate local oxygen control in early hypertensive vascular resistance; hypothesis-generating for human studies.

Structured PICO

Does elevated oxygen exposure increase arteriole constriction in spontaneously hypertensive rats compared to normotensive controls?

Population

Spontaneously hypertensive rats (SHR) in the early (4- to 6-wk-old) and rapidly developing (8- to 9-wk-old) stages of hypertension, and age-matched normotensive Wistar-Kyoto (WKY) controls

Intervention

Elevation of superfusion solution PO2 (changing gas equilibration mixture from 0 to 5% O2) after blocking active neurogenic tone with 0.1 microgram/ml tetrodotoxin

Comparator

Age-matched normotensive Wistar-Kyoto (WKY) controls undergoing the same procedure

Outcome

Constriction and incidence of complete closure of first- (1A), second- (2A), third- (3A), and fourth-order (4A) arterioles in the cremaster musclesurrogate

Oxygen-related local control mechanisms may contribute to increased skeletal muscle vascular resistance early in the development of hypertension.

Cite This Study

Lombard et al. (1986) studied this question.

synapsesocial.com/papers/6a83ba67d5cebee0d06a888e https://doi.org/10.1152/ajpheart.1986.250.5.h761

Topics

Hypertension management

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Enhanced response of arterioles to oxygen during development of hypertension in SHR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Enhanced response of arterioles to oxygen during development of hypertension in SHR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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