What question did this study set out to answer?

To review microcirculatory hemodynamic changes and vascular remodeling across experimental models of spontaneous and renovascular hypertension.

March 1, 1983Hypertension

The microcirculation in experimental hypertension. State-of-the-art review.

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Population

Experimental models of hypertension including the SHR strain of rats, renovascular forms of the disease in…

Design

Review

Authors

BZB W ZweifachScripps Research Institute

Discussion

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Implication

Supports microvascular rarefaction mechanisms in experimental hypertension; leaves open translation to human disease and therapy.

Key Points

To review microcirculatory hemodynamic changes and vascular remodeling across experimental models of spontaneous and renovascular hypertension.
Synthesized intravital microscopy findings of skeletal muscle, splanchnic viscera, and hamster cheek pouch preparations.
Evaluated arteriolar diameter, pressure, and blood flow alterations primarily in spontaneously hypertensive rats (SHR) and surgical renovascular models.
Microvascular measurements in skeletal muscle reveal a 2- to 3-fold elevation in flow resistance emerging in terminal and precapillary arterioles by 4 weeks of age in SHR.
Smaller peripheral arterioles (15–25 µm) demonstrate functional rarefaction, shutting down 30% to 50% of precapillary extensions from active circulation.
Structural rarefaction (loss of vessel density) manifests only in late-stage disease and accounts for a minor component of total peripheral resistance.

Structured PICO

Population

Experimental models of hypertension including the SHR strain of rats, renovascular forms of the disease in rats, and hamsters

Outcome

Microvascular resistance and rarefaction

In experimental hypertension, increased microvascular resistance is driven initially by functional rarefaction and later by structural rarefaction of arterioles.

Cite This Study

B W Zweifach (1983) studied this question.

synapsesocial.com/papers/6a6f9b9d75498292b708fc8b https://doi.org/10.1161/01.hyp.5.2_pt_2.i10

Topics

Hypertension management

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The microcirculation in experimental hypertension. State-of-the-art review.

Discussion

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Implication

Key Points

Structured PICO

Cite This Study

Topics

The microcirculation in experimental hypertension. State-of-the-art review.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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