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October 1, 1965Circulation Research

In Vitro Demonstration of Vascular Hyper-responsiveness in Experimental Hypertension

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Population

Ventral caudal artery from DCA hypertensive and control rats

Comparison

In vitro perfusion with vasoconstrictors vs Arteries from normotensive control rats

Design

Preclinical

Authors

JHJ. A. M. HinkeUniversity of British ColumbiaPSP. SimpsonUniversity of British Columbia

Discussion

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Implication

Hypothesis-generating in rat models; leaves open translation to human hypertensive vasculopathy.

Structured PICO

P
Population
Ventral caudal artery from DCA hypertensive and control rats
I
Intervention
In vitro perfusion with vasoconstrictors (norepinephrine, vasopressin, angiotensin II, or rat serum)
C
Comparator
Arteries from normotensive control rats
O
Outcome
Vascular responsiveness (strength of muscular contraction, wall tension, flow, and diameter)surrogate

Experimental hypertension induces structural thickening and hyper-responsiveness to vasoconstrictors in rat arteries.

Cite This Study

Hinke et al. (1965) studied this question.

synapsesocial.com/papers/6a7e27f3fdb0e04bb5e97129https://doi.org/10.1161/01.res.17.4.359

Topics

Hypertension management
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Also Consider

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  5. 5Effects of Aldosterone on Blood Pressure and Electrolyte Distribution in the Rat1958 · 11 citations