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June 1, 1966Circulation Research

Effect of Ca ++ upon Contractility of Small Arteries from DCA-Hypertensive Rats

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Population

Segments of the ventral tail artery from DCA-hypertensive and normotensive rats

Comparison

Addition of norepinephrine or increasing K+… vs Normotensive rat artery segments

Design

Preclinical

Authors

JHJ. A. M. HinkeUniversity of British Columbia

Discussion

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Implication

May indicate altered Ca++ handling in hypertensive vessels; leaves open translation to human disease mechanisms.

Structured PICO

P
Population
Segments of the ventral tail artery from DCA-hypertensive and normotensive rats
I
Intervention
Addition of norepinephrine or increasing K+ concentration, followed by removing and re-adding Ca++ to the perfusate
C
Comparator
Normotensive rat artery segments
O
Outcome
Arterial contractility and hyperresponsiveness (work performed, response to zero Ca++ perfusion, and Ca++ required to re-establish contraction)surrogate

DCA-hypertensive rat arteries exhibit hyperresponsiveness linked to altered calcium utilization or contractile mechanisms.

Cite This Study

J. A. M. Hinke (1966) studied this question.

synapsesocial.com/papers/6a834a3bc32884adb2ae36cbhttps://doi.org/10.1161/01.res.18.s6.i-23
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In Vitro Demonstration of Vascular Hyper-responsiveness in Experimental Hypertension1965 · 57 citations
  2. 2Calcium and the contractility of arterial smooth muscle1964 · 84 citations
  3. 3Changes in Extracellular Ca<sup>2+</sup>Over a Physiologic Concentration Range Differentially Modulate Reactivity of Resistance Arteries of Spontaneously Hypertensive and Normotensive Rats1993 · 8 citations
  4. 4Role of Ca<sup>+</sup>‐dependent K‐channels in the membrane potential and contractility of aorta from spontaneously hypertensive rats1994 · 25 citations
  5. 5Control of vascular tone in isolated mesenteric arterial segments from hypertensive patients1999 · 27 citations