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November 1, 1994British Journal of PharmacologyOpen Access

Role of Ca+‐dependent K‐channels in the membrane potential and contractility of aorta from spontaneously hypertensive rats

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Why the study?

Does blockade of Ca2+-dependent K-channels alter membrane potential and contractility in aortae from hypertensive and normotensive rats?

Population

Aortic rings from spontaneously hypertensive rats, normotensive Wistar rats, and Wistar Kyoto rats

Comparison

Ca2+-dependent K-channel blockers vs Absence of Ca2+-dependent K-channel blockers

Design

Preclinical

Authors

ESEneida G. SilvaAssociação Paulista de MedicinaEFEugenio Frediani‐NetoAssociação Paulista de MedicinaAFAlice T. FerreiraAdministração Regional de Saúde de Lisboa e Vale do Tejo

Discussion

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Implication

No immediate clinical implications; leaves open whether K-channel blockade merits human hypertension trials.

Structured PICO

Does blockade of Ca2+-dependent K-channels alter membrane potential and contractility in aortae from hypertensive and normotensive rats?

P
Population
Aortic rings from spontaneously hypertensive rats (SHR), normotensive Wistar rats (NWR), and Wistar Kyoto rats (WKY)
I
Intervention
Ca2+-dependent K-channel blockers (apamin and tetraethylammonium [TEA])
C
Comparator
Absence of Ca2+-dependent K-channel blockers
O
Outcome
Contractile responses to KCl and membrane potentialssurrogate

Overactivity of Ca2+-dependent K-channels in aortae of spontaneously hypertensive rats contributes to higher membrane potentials and reduced responsiveness to vasoconstrictor stimuli.

Cite This Study

Silva et al. (1994) studied this question.

synapsesocial.com/papers/6a70dd12e5469ee92be189f4https://doi.org/10.1111/j.1476-5381.1994.tb17095.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced single-channel K+ current in arterial membranes from genetically hypertensive rats1993 · 82 citations
  2. 2Contractile responses to ouabain and K+-free solution in aorta from hypertensive rats1986 · 18 citations
  3. 3Measurement of calcium influx in tethered rings of rabbit aorta under tension1985 · 5 citations
  4. 4BK<sub>1</sub> and BK<sub>2</sub> bradykinin receptors in the rat duodenum smooth muscle1992 · 14 citations
  5. 5Intracellular ion activities in frog skin in relation to external sodium and effects of amiloride and/or ouabain.1984 · 81 citations