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January 1, 1964American Journal of Physiology-Legacy Content

Calcium and the contractility of arterial smooth muscle

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Population

Isolated arterial segment (500 µ o.d.)

Comparison

Stimulation with high K+, norepinephrine, and… vs Perfusion with zero [Ca++]0

Design

Preclinical

Authors

JHJ. A. M. HinkeUniversity of British ColumbiaMWM. L. WilsonUniversity of British ColumbiaSBSamantha C. BurnhamEli Lilly (United States)

Discussion

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Implication

Differential Ca2+ thresholds in arterial contractions should not change practice; leaves open mechanistic validation in human models.

Structured PICO

P
Population
Isolated arterial segment (500 µ o.d.)
I
Intervention
Stimulation with high K+, norepinephrine, and Pitressin under varying extracellular calcium concentrations ([Ca++]0)
C
Comparator
Perfusion with zero [Ca++]0
O
Outcome
Contraction measured as a reduction in flow through its lumen at a constant perfusing pressuresurrogate

This preclinical study demonstrates that calcium is utilized differently by potassium depolarization compared to drug stimulation to induce arterial smooth muscle contraction.

Cite This Study

Hinke et al. (1964) studied this question.

synapsesocial.com/papers/6a88f9ed4f37e970fb7b3ec1https://doi.org/10.1152/ajplegacy.1964.206.1.211
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contractile Responses of Isolated Rabbit Aortae to Transmural Stimulation as Affected by Calcium, Strontium, Sodium and Ouabain1972
  2. 2Effect of Ca <sup>++</sup> upon Contractility of Small Arteries from DCA-Hypertensive Rats1966 · 33 citations
  3. 3Role of Calcium in Contractile Excitation of Vascular Smooth Muscle by Epinephrine and Potassium1962 · 67 citations
  4. 4ON THE ROLES OF CALCIUM ION DURING POTASSIUM INDUCED CONTRACTURE IN THE SMOOTH MUSCLE CELLS OF THE RABBIT MAIN PULMONARY ARTERY1977 · 31 citations
  5. 5Effects of electrolytes on contractility of artery segments in vitro1962 · 26 citations