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January 1, 1977The Japanese Journal of PhysiologyOpen Access

On the Roles of Calcium Ion During Potassium Induced Contracture in the Smooth Muscle Cells of the Rabbit Main Pulmonary Artery

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Population

Smooth muscle cells of the rabbit main pulmonary artery

Comparison

Exposure to excess potassium and various… vs Standard Krebs solution or varying extracellular…

Design

Preclinical

Authors

YIYushi ItoKurume UniversityHSHikaru SuzukiTokyo University of Agriculture and TechnologyHKHirosi KuriyamaSeinan Jo Gakuin University

Discussion

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Overview

Should not change clinical practice; leaves open mechanistic role of Ca++ influx in human pulmonary arteries.

Structured PICO

P
Population
Smooth muscle cells of the rabbit main pulmonary artery
I
Intervention
Exposure to excess potassium (K+) and various chemical agents (noradrenaline, acetylcholine, prostaglandin F2alpha) under different calcium conditions
C
Comparator
Standard Krebs solution or varying extracellular potassium concentrations
O
Outcome
Mechanical response (contracture) and membrane depolarizationsurrogate

In rabbit pulmonary artery smooth muscle cells, potassium-induced contracture is primarily driven by calcium influx rather than membrane depolarization.

Cite This Study

Ito et al. (1977) studied this question.

synapsesocial.com/papers/6a8387d2afb287de3d96096fhttps://doi.org/10.2170/jjphysiol.27.755
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Link Between Agonist Action and Response in Smooth Muscle1971 · 135 citations
  2. 2Some differences in contractile responses of isolated longitudinal and circular muscle from the guinea‐pig stomach.1975 · 39 citations
  3. 3THE RELATIONSHIP BETWEEN THE ELECTRICAL AND MECHANICAL ACTIVITY OF THE GUINEA-PIG STOMACH1970 · 22 citations
  4. 4ELECTRICAL ACTIVITY OF GUINEA-PIG TAENIA COLI IN CALCIUM LOCKE SOLUTION1971 · 10 citations