Key result
Acetylcholine triggers depolarized muscle contractions without extracellular calcium via potassium-enhanced myoplasm sensitivity.
Population
Depolarized aortic muscle of the turtle and stomach muscle of the frog
Comparison
Acetylcholine and calcium in various ionic… vs Different ionic environments
Design
Preclinical
Authors
Loading...
Caution against assuming extracellular Ca²⁺ dependence in all smooth muscle; leaves open potassium-mediated myoplasmic sensitivity for translational research.
This basic science study demonstrates that extracellular calcium is not strictly essential for acetylcholine-induced contraction in depolarized smooth muscle, highlighting the role of potassium in modulating myoplasm sensitivity.
Isojima et al. (1963) studied this question. Acetylcholine and Calcium was evaluated on Muscle contraction. Extracellular calcium is not essential for acetylcholine-induced contractions in depolarized turtle aortic and frog stomach muscles, depending instead on increased myoplasm sensitivity from potassium.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: