January 1, 1982The Journal of PhysiologyOpen Access

Roles of stored calcium on the mechanical response evoked in smooth muscle cells of the porcine coronary artery

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Population

Intact and skinned smooth muscle cells of the porcine coronary artery

Design

Preclinical

Authors

TITakeo ItohNihon Fukushi University MKMakoto KajiwaraKureha (Japan)KKKenji KitamuraUniversity of Florida

Discussion

Member takes

Implication

Should not guide clinical coronary vasomotor management; leaves open direct acetylcholine action on intracellular calcium sites.

Structured PICO

Population

Intact and skinned smooth muscle cells of the porcine coronary artery

Intervention

Acetylcholine (10(-8)-10(-5) M), caffeine (0.3-5 mM), and procaine (1-5 mM)

Outcome

Membrane potential, membrane resistance, and mechanical contraction/tensionsurrogate

This preclinical study elucidates the mechanisms by which acetylcholine, caffeine, and procaine modulate calcium release and contraction in porcine coronary artery smooth muscle cells.

Cite This Study

Itoh et al. (1982) studied this question.

synapsesocial.com/papers/6a870ee5b712452940cbb561 https://doi.org/10.1113/jphysiol.1982.sp014026

View Full Paper

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Roles of stored calcium on the mechanical response evoked in smooth muscle cells of the porcine coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Roles of stored calcium on the mechanical response evoked in smooth muscle cells of the porcine coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider