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August 1, 1982The Journal of General PhysiologyOpen Access

Intracellular Ca release in skinned smooth muscle.

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Population

Saponin-treated skinned smooth muscle of guinea pig taenia caecum

Design

Preclinical

Authors

KSK SaidaKobe City Medical Center General Hospital

Discussion

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Implication

Hypothesis-generating for dual Ca release in smooth muscle; leaves open translation to human physiology or therapy.

Structured PICO

P
Population
Saponin-treated skinned smooth muscle of guinea pig taenia caecum
I
Intervention
Exposure to varying concentrations of calcium, magnesium, and replacement of propionate with chloride
O
Outcome
Amount of intracellular calcium released (estimated by the area under the contraction curve during treatment with 25 mM caffeine)surrogate

This preclinical study demonstrates that intracellular calcium release in smooth muscle is mediated by both calcium-induced and depolarization-induced mechanisms.

Cite This Study

K Saida (1982) studied this question.

synapsesocial.com/papers/6a8a6caf1fb56efa37d49c66https://doi.org/10.1085/jgp.80.2.191
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characteristics of Ca2+- and Mg2+-induced tension development in chemically skinned smooth muscle fibers.1978 · 194 citations
  2. 2Effects of magnesium on contractile activation of skinned cardiac cells.1975 · 216 citations
  3. 3Regenerative Calcium Release within Muscle Cells1970 · 395 citations
  4. 4Depolarization of the Internal Membrane System in the Activation of Frog Skeletal Muscle1967 · 134 citations
  5. 5Excitation-Contraction Coupling of Isolated Cardiac Fibers with Disrupted or Closed Sarcolemmas: CALCIUM-DEPENDENT CYCLIC AND TONIC CONTRACTIONS1972 · 215 citations