Key result
In chemically skinned smooth muscle fibers, Ca2+-induced tension development required >1 mM Mg2+, and Mg2+ >2 mM caused slow tension development in the absence of Ca2+.
Population
Chemically skinned smooth muscle fibers from guinea pig taenia caecum prepared by saponin treatment
Design
Preclinical
Authors
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Ca2+ thresholds in skinned fibers warrant no clinical change; leaves open translation to cardiovascular smooth muscle regulation.
The study demonstrates that Ca2+-induced tension development in smooth muscle requires Mg2+ and differs substantially from skeletal muscle in its response to MgATP.
Saida et al. (1978) studied this question. Ca2+ and Mg2+ was evaluated on Tension development. In chemically skinned smooth muscle fibers, Ca2+-induced tension development required >1 mM Mg2+, and Mg2+ >2 mM caused slow tension development in the absence of Ca2+.
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