March 1, 1984AJP Cell Physiology

Effect of calmodulin, Ca2+, and cAMP protein kinase on skinned tracheal smooth muscle

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Population

Membrane skinned smooth muscle from guinea pig trachealis muscle

Comparison

Calmodulin, Ca2+, cAMP protein kinase… vs Control conditions

Design

Preclinical

Authors

MSM P SparrowAustralian National University GPGabriele PfitzerGeneral Cardiology MGM. GagelmannCedars-Sinai Medical Center

Discussion

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Implication

Calmodulin effects on tracheal smooth muscle remain preclinical; animal data leaves open any role in human airway disorders.

Structured PICO

Population

Membrane skinned smooth muscle from guinea pig trachealis muscle

Intervention

Calmodulin (0.1-10 microM), Ca2+, cAMP protein kinase, trifluoperazine, adenosine 5'-O-(3-thiotriphosphate)

Comparator

Control conditions (absence of Ca2+, different temperatures and pH levels)

Outcome

Characteristics of contraction and relaxation (tension development, speed of contraction, threshold Ca2+ concentration)surrogate

The study demonstrates that calmodulin enhances Ca2+-induced contraction in skinned tracheal smooth muscle, while cAMP-dependent protein kinase inhibits tension development, consistent with myosin-linked regulation.

Cite This Study

Sparrow et al. (1984) studied this question.

synapsesocial.com/papers/6a7e8b07d14c4cd804797ead https://doi.org/10.1152/ajpcell.1984.246.3.c308

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Effect of calmodulin, Ca2+, and cAMP protein kinase on skinned tracheal smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of calmodulin, Ca2+, and cAMP protein kinase on skinned tracheal smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider