July 1, 1986The Journal of PhysiologyOpen Access

Inorganic phosphate regulates the contraction‐relaxation cycle in skinned muscles of the rabbit mesenteric artery.

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Population

Chemically skinned smooth muscles of the rabbit mesenteric artery

Comparison

Inorganic phosphate (Pi) application (over 1 mM) vs Control conditions without Pi

Design

Preclinical

Authors

TIT ItohSeinan Jo Gakuin University YKYuichi KanmuraFujieda Municipal General Hospital HKH KuriyamaKowa (Japan)

Discussion

Member takes

Implication

May modulate vascular tone via cross-bridge kinetics in animal vessels; leaves open human relevance and clinical translation.

Structured PICO

Population

Chemically skinned smooth muscles of the rabbit mesenteric artery

Intervention

Inorganic phosphate (Pi) application (over 1 mM)

Comparator

Control conditions without Pi

Outcome

Ca2+-dependent and Ca2+-independent contractions and relaxation ratessurrogate

Inorganic phosphate accelerates the detachment of cross-bridges between contractile proteins in rabbit mesenteric artery smooth muscle, slightly inhibiting contraction and markedly facilitating relaxation.

Cite This Study

Itoh et al. (1986) studied this question.

synapsesocial.com/papers/6a756dffe42ca79ec1e717ce https://doi.org/10.1113/jphysiol.1986.sp016151

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