Population
Skinned (demembranated) rat tail arterial smooth muscle
Design
Preclinical
Authors
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Challenges classical calmodulin model in smooth muscle; leaves open translational relevance to human cardiovascular therapies.
This study revises the classical model of smooth muscle contraction by showing that calmodulin is pre-bound to myofilaments rather than freely floating in the cytosol at resting calcium levels.
Wilson et al. (2002) studied this question.
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