Key result
Calcium-dependent caldesmon disinhibition can trigger vascular smooth muscle contraction without prior MLC phosphorylation.
Authors
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No immediate change to vascular tone management; leaves open caldesmon disinhibition's role in human cardiovascular disease.
Zhang et al. (1994) studied Vascular smooth muscle contraction. Vascular smooth muscle contraction can be initiated by a Ca(2+)-dependent mechanism that does not require prior myosin light chain phosphorylation, likely via caldesmon disinhibition.
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