Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1981AJP Cell Physiology

Myosin light chain phosphorylation associated with contraction in arterial smooth muscle

View Full Paper
Ask AI
Bookmark
Share

Population

Tissues prepared from the media of swine carotid arteries

Comparison

Stimulation with a high-K+ physiological salt… vs Unstimulated tissues with low levels of tone

Design

Preclinical

Follow-up

10 minutes

Authors

SDSteven P. DriskaTemple UniversityMAM. O. AksoyHacettepe UniversityRMRichard A. MurphyUniversity of Southern California

Discussion

Loading...

Member takes

Implication

LC20 phosphorylation initiates but does not sustain arterial tone; leaves open identification of maintenance factors for further study.

Structured PICO

P
Population
Tissues prepared from the media of swine carotid arteries
I
Intervention
Stimulation with a high-K+ physiological salt solution containing 1.6 mM CaCl2
C
Comparator
Unstimulated tissues with low levels of tone
O
Outcome
Myosin light chain (LC 20) phosphorylation and force developmentsurrogate

Ca2+-stimulated LC 20 phosphorylation initiates contraction in arterial smooth muscle, but additional factors are required to maintain tonic isometric force.

Cite This Study

Driska et al. (1981) studied this question.

synapsesocial.com/papers/6a7027f653da1ffdb5079d82https://doi.org/10.1152/ajpcell.1981.240.5.c222
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ca2+ Dependent Phosphorylation of Bovine Aortic Actomyosin1978 · 58 citations
  2. 2Phosphorylation of the light-chain components of myosin from cardiac and red skeletal muscles1975 · 164 citations
  3. 3Does Phosphoryiation of Myosin Light Chain Have Direct Relation to Regulation in Smooth Muscle?11977 · 56 citations
  4. 4Length-Tension Relationship of Smooth Muscle of the Hog Carotid Artery1973 · 311 citations
  5. 5Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation.1977 · 305 citations