August 1, 1980Journal of Biological ChemistryOpen Access

Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.

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Population

Intact arterial smooth muscle

Design

Preclinical

Authors

JBJohn T. BarronWilmington University MBMichael BárányUniversity of Edinburgh KBKate BárányWestchester Institute for Human Development

Discussion

Member takes

Implication

Hypothesis-generating for Ca2+-dependent arterial tone regulation; should not yet change clinical practice in vascular disorders.

Structured PICO

Population

Intact arterial smooth muscle

Intervention

Application of pharmacological contractile agonists and antagonists, EGTA, and calmodulin inhibitors (antipsychotic drugs)

Outcome

Myosin light chain phosphorylation levels and contractile statesurrogate

Demonstrates that calcium- and calmodulin-dependent myosin light chain phosphorylation regulates the contraction-relaxation cycle in intact arterial smooth muscle.

Cite This Study

Barron et al. (1980) studied this question.

synapsesocial.com/papers/6a86dab3e0e6abca40d3baf2 https://doi.org/10.1016/s0021-9258(18)43729-5

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Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider