November 24, 2000Biochemical JournalOpen Access

The involvement of protein kinase C in myosin phosphorylation and force development in rat tail arterial smooth muscle

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Population

Rat tail arterial smooth-muscle strips (RTA)

Design

Preclinical

Authors

LWLynn P. WeberUniversity of Saskatchewan MSMinoru SetoAsahi Kasei (Germany)YSYasuharu SasakiNational Center for Global Health and Medicine

Discussion

Member takes

Implication

Highlights differential kinase roles in arterial contraction; leaves open relevance to human vascular disorders pending validation.

Structured PICO

Population

Rat tail arterial smooth-muscle strips (RTA)

Intervention

MLCK inhibitors (ML-9 and wortmannin) and PKC inhibitors (chelerythrine and calphostin C)

Outcome

Myosin light-chain (LC(20)) phosphorylation and force developmentsurrogate

In rat tail arterial smooth muscle, basal myosin light-chain phosphorylation is mediated by MLCK, whereas alpha(1)-adrenoceptor stimulation involves both MLCK and PKC.

Cite This Study

Weber et al. (2000) studied this question.

synapsesocial.com/papers/6a843f866e9d0d88c0bd97f5 https://doi.org/10.1042/bj3520573

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The involvement of protein kinase C in myosin phosphorylation and force development in rat tail arterial smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The involvement of protein kinase C in myosin phosphorylation and force development in rat tail arterial smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider