What does this research mean for the field?

In skinned muscle fibers, increasing concentrations of Mg-ATP systematically shift tension-pCa curves to the right and reduce the maximum calcium-activated tension at sufficiently high concentrations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1977AJP Cell Physiology

Regulation of tension in skinned muscle fibers: effect of high concentrations of Mg-ATP

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Population

skinned muscle fibers

Design

Preclinical

Authors

MOM. OrentlicherMorpho (United States)PBPhilip W. BrandtUniversity of Calgary JRJ. P. ReubenUniversidade Federal do Rio de Janeiro

Discussion

Member takes

Implication

Skinned fiber Mg-ATP effects require intact-muscle validation; leaves open relevance to human cardiac contractility.

Structured PICO

Population

skinned muscle fibers

Intervention

high concentrations of Mg-ATP over a wide range of temperature and salt concentration

Outcome

tension in skinned fiberssurrogate

In skinned muscle fibers, high concentrations of Mg-ATP decrease maximum Ca-activated tension and shift the tension-pCa curve to the right.

Cite This Study

Orentlicher et al. (1977) studied this question.

synapsesocial.com/papers/6a15fc60a215942ca9e3f4e5 https://doi.org/10.1152/ajpcell.1977.233.5.c127

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Regulation of tension in skinned muscle fibers: effect of high concentrations of Mg-ATP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of tension in skinned muscle fibers: effect of high concentrations of Mg-ATP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider