December 1, 1992The Journal of PhysiologyOpen Access

Contribution of Ca(2+)‐induced Ca2+ release to the Ca2+i transients in myocytes from guinea‐pig urinary bladder.

View Full Paper

Ask AI

Bookmark

Population

Smooth muscle cells from guinea-pig urinary bladder

Comparison

Membrane depolarization and pharmacological agents vs Baseline/control conditions

Design

Preclinical

Authors

VGVladimir GanitkevichJena University Hospital GIG IsenbergElectrophysiology

Discussion

Member takes

Implication

Animal data implicate CICR in detrusor Ca2+ transients; leaves open translation to human bladder function or therapy.

Structured PICO

Population

Smooth muscle cells from guinea-pig urinary bladder

Intervention

Membrane depolarization and pharmacological agents (caffeine, ryanodine, thapsigargin, Bay K 8644)

Comparator

Baseline/control conditions

Outcome

Cytosolic calcium concentration ([Ca2+]i) transients (phasic and tonic components)surrogate

In guinea-pig urinary bladder smooth muscle cells, depolarization-induced Ca2+ influx through L-type channels triggers Ca2+ release from intracellular stores, which primarily constitutes the phasic component of the calcium transient.

Cite This Study

Ganitkevich et al. (1992) studied this question.

synapsesocial.com/papers/6a82c64d68df11fa7b6d05db https://doi.org/10.1113/jphysiol.1992.sp019409

View Full Paper

Ask AI

Bookmark

Contribution of Ca(2+)‐induced Ca2+ release to the Ca2+i transients in myocytes from guinea‐pig urinary bladder.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contribution of Ca(2+)‐induced Ca2+ release to the Ca2+i transients in myocytes from guinea‐pig urinary bladder.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider