Population
Voltage-clamped guinea-pig coronary myocytes
Comparison
Application of 10 mM caffeine, sodium removal… vs Resting state or absence of intervention
Design
Preclinical
Authors
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Should not change coronary disease management; hypothesis-generating for NCX-triggered Ca2+ release in myocytes, requiring higher-species validation.
In Na+-loaded guinea-pig coronary myocytes, Ca2+ entry through Na+-Ca2+ exchange can trigger Ca2+ release from intracellular stores.
VYa et al. (1993) studied this question.
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