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September 1, 1979The Journal of PhysiologyOpen Access

Effects of acetylcholine and catecholamines on the smooth muscle cell of the porcine coronary artery.

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Population

Smooth muscle cells of the pig coronary artery

Design

Preclinical

Authors

YIYushi ItoKKKenji KitamuraHKH Kuriyama

Discussion

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Overview

Porcine coronary data show ACh-induced contraction independent of membrane potential; leaves open translation to human vasomotor control.

Structured PICO

P
Population
Smooth muscle cells of the pig coronary artery
I
Intervention
Acetylcholine (ACh), noradrenaline (NA), and isoprenaline (Isop)
O
Outcome
Membrane and mechanical properties (membrane potential, membrane resistance, contraction)surrogate

In porcine coronary arteries, muscarinic activation induces contraction without changing membrane potential, while beta-adrenergic activation hyperpolarizes the membrane and suppresses contraction.

Cite This Study

Ito et al. (1979) studied this question.

synapsesocial.com/papers/6a7239e3f44fa9f079dfc80chttps://doi.org/10.1113/jphysiol.1979.sp012948
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The membrane properties of the smooth muscle cells of the rabbit main pulmonary artery1977 · 199 citations
  2. 2ON THE ROLES OF CALCIUM ION DURING POTASSIUM INDUCED CONTRACTURE IN THE SMOOTH MUSCLE CELLS OF THE RABBIT MAIN PULMONARY ARTERY1977 · 31 citations
  3. 3Electrical Quiescence of Pulmonary Artery Smooth Muscle During Sympathomimetic Stimulation1964 · 110 citations
  4. 4Na—Ca exchange and tension development in arterial smooth muscle1973 · 301 citations
  5. 5Current spread in the smooth muscle of the rabbit aorta1974 · 82 citations