Key result
Nitroglycerine reduced resting tension and suppressed contraction evoked by excess potassium, electrical depolarization, or phenylephrine in canine coronary arteries without affecting membrane properties.
Population
Smooth muscle cells of the canine and porcine coronary artery
Design
Preclinical
Authors
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These in vitro TEA effects extend basic coronary electrophysiology; clinical relevance to vasomotion remains undetermined.
Nitroglycerine relaxes canine coronary artery smooth muscle cells by suppressing contraction mechanisms without altering resting membrane electrical properties.
Ito et al. (1980) studied this question. Nitroglycerine and catecholamines was evaluated on Membrane potential and contraction of smooth muscle cells. Nitroglycerine reduced resting tension and suppressed contraction evoked by excess potassium, electrical depolarization, or phenylephrine in canine coronary arteries without affecting membrane properties.
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