Population
Isolated coronary artery of the pig (smooth muscle cells)
Comparison
Nitroglycerine at various concentrations (10 to… vs Control conditions
Design
Preclinical
Authors
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Nitroglycerin may suppress coronary smooth muscle contraction via calcium mobilization; leaves open translation to human physiology or dosing.
Nitroglycerine suppresses contraction in pig coronary artery smooth muscle cells primarily through nonselective suppression of calcium mobilization rather than changes in membrane properties at physiological concentrations.
Ito et al. (1980) studied this question.
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