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July 1, 1971The Journal of General PhysiologyOpen Access

Studies of Cardiac Muscle with a High Permeability to Calcium Produced by Treatment with Ethylenediaminetetraacetic Acid

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Population

Isolated frog ventricle strips and rabbit right ventricular papillary muscle

Comparison

Treatment with 3 mM EDTA for 15 min followed by… vs Pre-EDTA twitch tension and contracture tension…

Design

Preclinical

Authors

SWSaul WinegardUniversity of Pennsylvania

Discussion

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Implication

Highlights Ca2+ sensitivity of cardiac myofilaments in EDTA-treated muscle; leaves open translation to intact human myocardium.

Structured PICO

P
Population
Isolated frog ventricle strips and rabbit right ventricular papillary muscle
I
Intervention
Treatment with 3 mM EDTA for 15 min followed by exposure to contracture solutions with varying free calcium concentrations (10^-4.8 M to 10^-9 M)
C
Comparator
Pre-EDTA twitch tension and contracture tension in KCl low Na-Ringer
O
Outcome
Muscle tension development in response to varying calcium concentrationssurrogate

EDTA treatment increases cardiac muscle membrane permeability to calcium, allowing direct activation of contractile elements by extracellular calcium concentrations.

Cite This Study

Saul Winegard (1971) studied this question.

synapsesocial.com/papers/6a766ef53da069e66cbd3104https://doi.org/10.1085/jgp.58.1.71
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ouabain contracture of frog heart: Ca45 movements and effect of EDTA1960 · 30 citations
  2. 2Parallel Response of Myofibrillar Contraction and Relaxation to Four Different Nucleoside Triphosphates1969 · 63 citations
  3. 3Force measurements in skinned muscle fibres1969 · 326 citations
  4. 4THE ULTRASTRUCTURE OF FROG VENTRICULAR CARDIAC MUSCLE AND ITS RELATIONSHIP TO MECHANISMS OF EXCITATION-CONTRACTION COUPLING1968 · 196 citations
  5. 5Role of magnesium in the relaxation of myofibrils1969 · 88 citations