Key result
Large responses of arteries to noradrenaline in simple Ca-free saline were due to persisting extracellular Ca or labile Ca stores, while small responses in cold EDTA depended on non-communicating stores.
Population
Arterial smooth muscle
Design
Preclinical
Authors
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Should not alter clinical vasopressor strategies; leaves open distinct Ca store roles in arterial contraction.
The study demonstrates that arterial smooth muscle contractions to noradrenaline in Ca-free saline rely on persisting extracellular Ca or labile Ca stores, whereas responses after cold EDTA exposure depend on non-communicating Ca stores.
W. R. Keatinge (1972) studied this question. Ca-free solutions with and without EDTA vs. Simple Ca-free saline was evaluated on Extracellular Ca and EDTA concentrations and Ca efflux. Large responses of arteries to noradrenaline in simple Ca-free saline were due to persisting extracellular Ca or labile Ca stores, while small responses in cold EDTA depended on non-communicating stores.
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