Population
Sheep carotid arteries
Comparison
Noradrenaline 0.1 mM in Ca-free saline vs Noradrenaline in saline with Ca 1.25 mM present
Design
Preclinical
Authors
Loading...
Does not yet alter clinical management of vascular tone; leaves open the role of resistant Ca stores in human arteries.
The study demonstrates that noradrenaline can induce contraction in calcium-deprived arterial smooth muscle by utilizing a resistant intracellular calcium store independent of membrane depolarization.
W. R. Keatinge (1972) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: