January 1, 1983The Japanese Journal of PharmacologyOpen Access

Differences and similarities in the noradrenaline- and caffeine-induced mechanical responses in the rabbit mesenteric artery

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Population

Rabbit mesenteric artery (intact and skinned muscles)

Comparison

Noradrenaline (NA) vs Caffeine

Design

Preclinical

Authors

TITakeo ItohNihon Fukushi University HSHikaru SuzukiTokyo University of Agriculture and Technology HKHirosi KuriyamaSeinan Jo Gakuin University

Discussion

Member takes

Implication

Supports distinct Ca handling by noradrenaline versus caffeine in arteries; extends mechanistic insights but leaves open human translation.

Structured PICO

Population

Rabbit mesenteric artery (intact and skinned muscles)

Intervention

Noradrenaline (NA)

Comparator

Caffeine

Outcome

Mechanical responses (contraction) and calcium behaviorsurrogate

Noradrenaline and caffeine induce contractions in rabbit mesenteric arteries through different mechanisms of calcium handling, with NA requiring intact cell membranes and promoting calcium re-accumulation.

Cite This Study

Itoh et al. (1983) studied this question.

synapsesocial.com/papers/6a916e9a372004c0b3c65be3 https://doi.org/10.1016/s0021-5198(19)60406-3

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Implication

Supports distinct Ca handling by noradrenaline versus caffeine in arteries; extends mechanistic insights but leaves open human translation.

Differences and similarities in the noradrenaline- and caffeine-induced mechanical responses in the rabbit mesenteric artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differences and similarities in the noradrenaline- and caffeine-induced mechanical responses in the rabbit mesenteric artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider