July 1, 1998The Journal of PhysiologyOpen Access

Mechanisms of Ca2+ sensitization of force production by noradrenaline in rat mesenteric small arteries

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Population

Intact and alpha-toxin-permeabilized rat mesenteric small arteries

Comparison

Noradrenaline (10 microM) vs Control conditions without noradrenaline

Design

Preclinical

Authors

CBCarsten Leander BuusUniversité de Bordeaux CAChristian AalkjærVascular / Pulmonary Vascular HNHolger NilssonUniversity of Gothenburg

Discussion

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Implication

PKC mediates noradrenaline Ca2+ sensitization in rat arteries; leaves open translation to human vascular tone or hypertension therapies.

Structured PICO

Population

Intact and alpha-toxin-permeabilized rat mesenteric small arteries

Intervention

Noradrenaline (10 microM)

Comparator

Control conditions without noradrenaline (e.g., K-PSS with 125 mM K+)

Outcome

Contractile responses, intracellular Ca2+ concentration ([Ca2+]i), and phosphorylation of the myosin light chain (MLC)surrogate

Noradrenaline-induced Ca2+ sensitization in rat mesenteric small arteries is associated with increased myosin light chain phosphorylation, likely mediated by decreased MLC phosphatase activity via protein kinase C.

Cite This Study

Buus et al. (1998) studied this question.

synapsesocial.com/papers/6a8d55509a08a4eedd7fe82d https://doi.org/10.1111/j.1469-7793.1998.577bk.x

View Full Paper

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Mechanisms of Ca2+ sensitization of force production by noradrenaline in rat mesenteric small arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of Ca2+ sensitization of force production by noradrenaline in rat mesenteric small arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider