July 21, 2001Clinical and Experimental Pharmacology and PhysiologyOpen Access

Mechanisms Of Endothelin‐1‐Induced Potentiation Of Noradrenaline Response In Rat Mesenteric Artery

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Population

Rat perfused mesenteric arteries (from normotensive and deoxycorticosterone acetate-salt hypertensive rats)

Comparison

Perfusion with subpressor dose of endothelin-1… vs Noradrenaline alone; normotensive control animals

Design

Preclinical

Authors

YMYasuo MatsumuraAmerican Pharmacists Association SKSatomi KitaJikei University School of Medicine TOTomoko OkuiNara Women's University

Discussion

Member takes

Implication

Hypothesis-generating for ET-1 pathways in hypertension; should not yet influence clinical practice.

Structured PICO

Population

Rat perfused mesenteric arteries (from normotensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats)

Intervention

Perfusion with subpressor dose of endothelin-1 (3 x 10^-10 mol/L), with or without PKC inhibitors (staurosporine, calphostin C) or Rho-kinase inhibitor (Y-27632)

Comparator

Noradrenaline alone; normotensive control animals

Outcome

Vasoconstrictor/pressor responses to noradrenalinesurrogate

Endothelin-1 potentiates noradrenaline-induced vasoconstriction via PKC and Rho-kinase pathways, a mechanism implicated in DOCA-salt hypertension.

Cite This Study

Matsumura et al. (2001) studied this question.

synapsesocial.com/papers/6a8be7e4b676b7d1a2fb859b https://doi.org/10.1046/j.1440-1681.2001.03484.x

Topics

Hypertension management

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Mechanisms Of Endothelin‐1‐Induced Potentiation Of Noradrenaline Response In Rat Mesenteric Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Mechanisms Of Endothelin‐1‐Induced Potentiation Of Noradrenaline Response In Rat Mesenteric Artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider