Key result
Endothelin is a potent contractile agonist in vascular and non-vascular muscle, eliciting responses partly via extracellular calcium entry and partly by release of endoperoxides.
Population
Isolated vascular and non-vascular preparations from rats, rabbits, and guinea-pigs, and anaesthetised…
Comparison
Endothelin at various concentrations (e.g., 1 x… vs Phenylephrine, KCl, or baseline
Design
Preclinical
Authors
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Hypothesis-generating in animal models; leaves open translation to human vascular therapies.
Endothelin acts as a potent contractile agonist in vascular and non-vascular tissues, mediating responses partly via extracellular calcium entry and endoperoxide release.
Eglen et al. (1989) studied this question. Endothelin (ET-1) was evaluated on Contractile responses and blood pressure effects. Endothelin is a potent contractile agonist in vascular and non-vascular muscle, eliciting responses partly via extracellular calcium entry and partly by release of endoperoxides.
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