October 1, 1991British Journal of PharmacologyOpen Access

Endothelium‐dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16–21) and other endothelin‐related peptides in the rat

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Population

Rat isolated superior mesenteric bed and anaesthetized rats

Comparison

Endothelin fragments (endothelin, its amide)… vs Acetylcholine and sodium nitroprusside

Design

Preclinical

Authors

SDStephen A. DouglasUniversity of Minnesota CHC. Robin HileyUniversity of Cambridge

Discussion

Member takes

Implication

Should not change practice; leaves open whether disulphide requirements inform endothelin-targeted therapies.

Structured PICO

Population

Rat isolated superior mesenteric bed (perfused with Krebs-Henseleit solution containing 10 microM indomethacin and precontracted with 100 microM methoxamine) and anaesthetized rats

Intervention

Endothelin fragments (endothelin (16-21), its amide), human and porcine proendothelins, alanyl-substituted analogues ([Ala3,11]endothelin-1, [Ala1,3,11,15]endothelin-1), and endothelin-3

Comparator

Acetylcholine and sodium nitroprusside (for vasorelaxation potency comparison)

Outcome

Vasorelaxation (in vitro) and systemic blood pressure effects/mean arterial pressure (in vivo)surrogate

This study demonstrates that both disulphide bonds in endothelins are required for endothelium-dependent vasorelaxation in the mesenteric bed, mediated by receptors distinct from those causing smooth muscle contraction.

Cite This Study

Douglas et al. (1991) studied this question.

synapsesocial.com/papers/6a71bc71febe604dd70a41ed https://doi.org/10.1111/j.1476-5381.1991.tb12428.x

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Endothelium‐dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16–21) and other endothelin‐related peptides in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelium‐dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16–21) and other endothelin‐related peptides in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider