February 1, 1991British Journal of PharmacologyOpen Access

Modulation by endothelium of the responses induced by endothelin‐1 and by some of its analogues in rat isolated aorta

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Population

Rat isolated aorta rings

Comparison

Endothelin-1 and its analogues vs Presence versus absence of vascular endothelium

Design

Preclinical

Authors

STS. TopouzisBaylor College of Medicine JHJ.P. HugginsDuke University JPJohn T. PeltonUniversity of Nebraska–Lincoln

Discussion

Member takes

Implication

Endothelium attenuates endothelin-1 potency via EDRF in rat aorta; hypothesis-generating for human vascular tone, should not change practice.

Structured PICO

Population

Rat isolated aorta rings

Intervention

Endothelin-1 and its analogues (sarafotoxin S6b, [Ala3,11]endothelin-1, [Ala1,15]endothelin-1, [Ala1,3,11,15]endothelin-1)

Comparator

Presence versus absence of vascular endothelium

Outcome

Contractile effects and tissue content of cyclic GMPsurrogate

Endothelin-1 contractions in rat aorta are modulated by the endothelium, likely through enhanced release of endothelium-derived relaxing factor (EDRF).

Cite This Study

Topouzis et al. (1991) studied this question.

synapsesocial.com/papers/6a8386e145d6ebe77211ab0e https://doi.org/10.1111/j.1476-5381.1991.tb12208.x

View Full Paper

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Implication

Endothelium attenuates endothelin-1 potency via EDRF in rat aorta; hypothesis-generating for human vascular tone, should not change practice.

Modulation by endothelium of the responses induced by endothelin‐1 and by some of its analogues in rat isolated aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation by endothelium of the responses induced by endothelin‐1 and by some of its analogues in rat isolated aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider