December 1, 1994British Journal of PharmacologyOpen Access

Different endothelin receptors involved in endothelin‐1‐ and sarafotoxin S6B‐induced contractions of the human isolated coronary artery

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Population

Human isolated coronary artery segments

Design

Preclinical

Authors

WBWillem A. BaxÇevre ve Şehircilik Bakanlığı ZAZohara AghaiLeiden University CTCorina L.J. VAN TrichtErasmus University Rotterdam

Discussion

Member takes

Implication

Differential ETA subtypes in human coronaries may affect antagonist selectivity; leaves open in vivo translation and clinical relevance.

Structured PICO

Population

Human isolated coronary artery segments (endothelium-intact and endothelium-denuded ring segments, and spirally cut strips)

Intervention

Endothelin receptor agonists (ET-1, sarafotoxin S6b, big-ET-1, ET-3) and antagonists (BQ-123, FR139317, phosphoramidon)

Outcome

Contractile response (agonist potency pD2 and antagonist affinity pKB)surrogate

ET-1 and sarafotoxin S6b induce contractions in human coronary arteries via distinct subtypes of the ETA receptor, and the preparation type (ring vs. strip) affects agonist and antagonist potencies.

Cite This Study

Bax et al. (1994) studied this question.

synapsesocial.com/papers/6a830abba353bb944193c83b https://doi.org/10.1111/j.1476-5381.1994.tb17162.x

View Full Paper

Ask AI

Bookmark

Different endothelin receptors involved in endothelin‐1‐ and sarafotoxin S6B‐induced contractions of the human isolated coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Different endothelin receptors involved in endothelin‐1‐ and sarafotoxin S6B‐induced contractions of the human isolated coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider