Population
Rat mesenteric small arteries (intact and endothelium-denuded) in a perfusion pressurized arteriograph
Comparison
Endothelin-1 and sarafotoxin S6c, with or… vs Absence of antagonists
Design
Preclinical
Authors
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ETB desensitization may limit sustained vasoconstriction in small arteries; extends rat model data but leaves open human translation.
This preclinical study demonstrates that both ETA and ETB receptors mediate vasoconstriction in rat small arteries, though ETB receptors produce a smaller effect and rapidly desensitize.
Sharifi et al. (1996) studied this question.