April 1, 1995Cardiovascular Research

Endothelin receptor subtypes in resistance arteries from humans and rats

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Population

Human subcutaneous resistance arteries and rat mesenteric resistance arteries

Comparison

Endothelin-1, ETB agonist sarafotoxin S6c, ETA… vs Responses without antagonists or with intact…

Design

Preclinical

Authors

LDLi DengUniversity of Science and Technology of China JLJay‐Shake LiAnhui University of Traditional Chinese Medicine ESErnesto L. SchiffrinMedical Council of Canada

Discussion

Member takes

Implication

ETA-selective antagonism may modulate resistance artery tone; leaves open clinical translation and ETB contributions in human disease.

Structured PICO

Population

Human subcutaneous resistance arteries and rat mesenteric resistance arteries

Intervention

Endothelin-1, ETB agonist sarafotoxin S6c, ETA selective antagonists BQ123 or BQ610, nitric oxide synthase inhibitor L-NAME

Comparator

Responses without antagonists or with intact endothelium

Outcome

Contractile responsessurrogate

ETA receptors are the primary endothelin receptor subtype mediating constriction in human subcutaneous and rat mesenteric resistance arteries, with a minor contribution from ETB receptors.

Cite This Study

Deng et al. (1995) studied this question.

synapsesocial.com/papers/6a75d144756843cacbb22f36 https://doi.org/10.1016/s0008-6363(96)88530-0

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