Population
Isolated rat pulmonary artery rings (2-3 mm ID) and intrapulmonary resistance arteries (100-150 microns ID)
Comparison
Endothelin-1 with or without ETA receptor… vs Control conditions
Design
Preclinical
Authors
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Regional ET receptor differences in rat pulmonary arteries should not yet guide human therapies; hypothesis-generating for vessel-specific endothelin blockade.
This study demonstrates regional differences in endothelin receptor mediation of vasoconstriction in the rat pulmonary vasculature, with ETA dominating in larger arteries and ETB in resistance vessels.
MacLean et al. (1994) studied this question.
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