Population
rat small pulmonary and renal arteries
Comparison
Endothelin-1 (ET-1) 30 nM vs Comparison between pulmonary and renal artery…
Design
Preclinical
Authors
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Indicates ET receptor subtypes resistant to BQ-123/BQ-788 in pulmonary arteries; leaves open translation to human pulmonary hypertension therapies.
ET-1 may activate ET receptor(s) insensitive to both BQ-123 and BQ-788 in rat small pulmonary arteries, highlighting tissue-specific differences in endothelin receptor pharmacology.
Kato et al. (2006) studied this question.
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