Roles of endothelin receptors in the regional and systemic vascular responses to ET‐1 in the anaesthetized ganglion‐blocked rat: use of selective antagonists
Why the study?
Do selective endothelin receptor antagonists alter the regional and systemic vascular responses to ET-1 in anesthetized ganglion-blocked rats?
Population
Anaesthetized ganglion-blocked rats
Comparison
Coinfusion of BQ-123, BQ-788, or PD 145065 with… vs ET-1 infusion alone
Design
Preclinical
Follow-up
70 minutes
Authors
Discussion
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Member takes
Implication
Caution against clinical use of selective ET antagonists; leaves open receptor-specific targeting in human vascular disease.
Structured PICO
Do selective endothelin receptor antagonists alter the regional and systemic vascular responses to ET-1 in anesthetized ganglion-blocked rats?
P
Population
Anaesthetized ganglion-blocked rats
I
Intervention
Coinfusion of BQ-123 (10 mmol kg-1 min-1), BQ-788 (10 nmol kg-1 min-1), or PD 145065 (10 nmol kg-1 min-1) with ET-1 (10 pmol kg-1 min-1) for 70 min
C
Comparator
ET-1 infusion alone
O
Outcome
Changes in mean arterial pressure, cardiac output, total peripheral resistance, and regional vascular resistance over 70 minutessurrogate
In the rat circulation, ETA receptors mediate the pressor and vasoconstrictor effects of ET-1, whereas ETB receptors predominantly limit these pressor effects.
Cite This Study
Allcock et al. (1995) studied this question.