Key result
Injection of Endothelin-1 into the periaqueductal gray area of rats caused complex haemodynamic changes, including increased blood pressure and decreased heart rate, mediated predominantly by ETA receptors.
Population
Anaesthetized rats
Comparison
Injection of Endothelin-1 into the dorsolateral… vs Baseline/control state without ET-1 or without…
Design
Preclinical
Authors
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Should not yet change clinical practice; leaves open central ETA receptor contributions to human cardiovascular regulation.
p-value: p=<0.05
In anaesthetized rats, ET-1 injected into the periaqueductal gray area induces pressor effects and hemodynamic changes that are predominantly mediated by ETA receptors.
D’Amico et al. (1996) studied this question. Endothelin-1 (ET-1) injection into the periaqueductal gray (PAG) area vs. ETA/ETB receptor antagonists (FR 139317, BQ-788, SB 209670) or control was evaluated on Mean arterial blood pressure and heart rate (p=<0.05). Injection of Endothelin-1 into the periaqueductal gray area of rats caused complex haemodynamic changes, including increased blood pressure and decreased heart rate, mediated predominantly by ETA receptors.
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