What is the clinical evidence from this study?

Study design: Other. Population: Hypertension. Intervention: Endothelin-1. Primary outcome: Arterial blood pressure and behavioral changes (p=<.01).

April 1, 1995Hypertension

Endothelin-1 in Rat Periaqueductal Gray Area Induces Hypertension Via Glutamatergic Receptors

Q: What are the key findings of this study?

Endothelin-1 injection into the rat periaqueductal gray area dose-dependently increased arterial blood pressure, an effect significantly decreased by NMDA receptor antagonists (P<.01).

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Key result

Endothelin-1 injection into the rat periaqueductal gray area dose-dependently increased arterial blood pressure, an effect significantly decreased by NMDA receptor antagonists (P<.01).

Population

Freely moving rats

Design

Preclinical

Authors

MDMichele D’AmicoGeneral Cardiology LBLiberato BerrinoCardio-Oncology SMSabatino MaioneAzienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli

Discussion

Member takes

Implication

Suggests central endothelin-NMDA pathways in rat BP control; hypothesis-generating for hypertension mechanisms, no clinical translation yet.

Structured PICO

Population

Freely moving rats used to investigate the effects of endothelin-1 injection into the periaqueductal gray area on cardiovascular function.

Intervention

Endothelin-1 injection into the dorsolateral periaqueductal gray area at doses ranging from 0.1 to 10 pmol, with or without glutamatergic or adrenergic antagonists

Outcome

Arterial blood pressure and behavioral changes (longitudinal rolling of the body)surrogate

Main Result

p-value: p=<.01

Endothelin-1 in the rat periaqueductal gray area induces hypertension and behavioral changes that are mediated by NMDA glutamatergic receptors and the adrenergic system.

Cite This Study

D’Amico et al. (1995) studied Hypertension. Endothelin-1 was evaluated on Arterial blood pressure and behavioral changes (p=<.01). Endothelin-1 injection into the rat periaqueductal gray area dose-dependently increased arterial blood pressure, an effect significantly decreased by NMDA receptor antagonists (P<.01).

synapsesocial.com/papers/6a9afb8f224bda8bbf7c4ef6 https://doi.org/10.1161/01.hyp.25.4.507

Topics

Hypertension management

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Implication

Suggests central endothelin-NMDA pathways in rat BP control; hypothesis-generating for hypertension mechanisms, no clinical translation yet.

Endothelin-1 in Rat Periaqueductal Gray Area Induces Hypertension Via Glutamatergic Receptors

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Topics

Endothelin-1 in Rat Periaqueductal Gray Area Induces Hypertension Via Glutamatergic Receptors

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider