Why the study?
Does selective endothelin receptor antagonism alter ET-1-induced changes in blood pressure, hematocrit, and platelet aggregation in anesthetized rabbits?
Population
Anesthetized rabbits
Comparison
FR 139317 or PD 145065 prior to ET-1 injection vs ET-1 alone (implied)
Design
Preclinical
Follow-up
15 minutes post-injection
Authors
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Supports ETA/ETB subtype specificity in rabbit ET-1 responses; leaves open translation to human cardiovascular therapy.
Does selective endothelin receptor antagonism alter ET-1-induced changes in blood pressure, hematocrit, and platelet aggregation in anesthetized rabbits?
In anesthetized rabbits, ET-1-induced vasoconstriction is predominantly mediated via the ETA receptor, whereas depressor and antiaggregatory actions are mediated by the ETB receptor.
McMurdo et al. (1993) studied this question.
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